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After his fateful Halloween night murder rampage in the quiet town of Haddonfield, Illinois years earlier, Michael Myers was incarcinated at the Smith's Grove Sanitarium maximum-security mental facility where he was treated by noted child behaviorist Dr. Samuel Loomis (Malcolm McDowell) -- the only person who truly understood Michael's evil nature.
Now, 17 years later, Michael (Tyler Mane) escapes from the mental institution on Halloween day and begins a murderous trek back to Haddonfield to continue his killing streak and seek resolution to events from his past.
He begins stalking a high school girl, Laurie Strode (Scout Taylor-Compton), and her friends, Annie (Danielle Harris) and Lynda (Kristina Klebe). When Dr. Loomis, now a successful author for his book on Michael, hears of his escape, he enlists the help of Haddonfield's Sheriff Brackett (Brad Dourif) to find and put and end to Michael's reign of terror.