This second film adaptation of Richard Matheson's science-fiction novel I Am Legend (the first version being The Last Man on Earth with Vincent Price) unfolds in a post-apocalyptic 1976. Charlton Heston is Robert Neville, the sole recipient of a serum that enabled him to survive an onslaught of germ warfare between Russia and China - which seemingly rendered him the last (normal) human alive.
Neville lives in a garish, antique-strewn L.A. penthouse. During the day, he roams through the vacant city. At night, he fends off a bloodthirsty horde of mutant scavengers garbed in Spanish inquisition robes and sunglasses, led by Matthias (Anthony Zerbe), a former television newscaster in his good ol' pre-mutant days.
Matthias and his half-human vampires want to kill Neville. Neville's last man on earth status is shattered when he comes across a group of young people, presided over by the sexy and cynical Lisa (Rosalind Cash). Neville begins to form an interest in her, as the two try to keep Matthias and his minions at bay.
The Omega Man was filmed in downtown Los Angeles on Saturday afternoons, an area that consists almost exclusively of office buildings, and therefore was suitably vacant at the the time of production. In 2007, Matheson's novel received yet another incarnation - this one with Will Smith in the Heston role.