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Five interlocking tales of terror follow the fates of a group of weary travelers who confront their worst nightmares — and darkest secrets — over the course of one long night on an empty and desolate stretch of desert highway.

Two guys are on the run from their past when they turn up, blood-splattered, at a lonely roadside diner; when an all-girl rock band's tour van breaks down, the girls have to rely on the kindness of strangers; when he has a car accident, a businessman is desperate for help from an unusual 911 operator; a frantic gunman bursts into a bar demanding to know the location of a girl in a photograph; and masked men create havoc when they interrupt a family vacation.