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After a plane crash, a young therapist, Claire (Anne Hathaway), is assigned by her mentor (Andre Braugher) to counsel the flight's five survivors. When they share their recollections of the incident—which some say include an explosion that the airline claims never happened—Claire is intrigued by Eric (Patrick Wilson), the most secretive of the passengers.

Just as Claire's professional relationship with Eric—despite her better judgment—blossoms into a romance, the survivors begin to disappear mysteriously, one by one. Claire suspects that Eric may hold all the answers and becomes determined to uncover the truth, no matter the consequences.