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AAA can't help the roadside emergency that is the Johnson Family Vacation. Even the onboard navigation system has a meltdown on Nate Johnson (Cedric The Entertainer) and his family's cross-country trek to their annual family reunion/grudge match.

Reluctantly along for the ride are Nate's wife (Williams), who's only in it for the kids; their rapper-wannabe son (Bow Wow); their teenage daughter (Solange Knowles) who's fashioned herself as the next Lolita; and their youngest (Gabby Soleil), whose imaginary dog Nate just can't seem to keep track of.

Can the Johnsons survive each other and all the obstacles the road throws at them to make it to Caruthersville, Missouri? Can they find Missouri?