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Newlyweds Simon Doyle (Armie Hammer) and Linnet Ridgeway (Gal Gadot) are honeymooning on a river cruise on the Nile when a murder takes place on the boat. Detective Hercule Poirot (Kenneth Branagh) is called upon to investigate and figure out who was responsible. There are plenty of suspects, including jilted lover Jacqueline de Bellefort (Emma Mackey).

Based on Agatha Christie's novel of the same name.