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The year is 2019. A mysterious plague has swept over the earth, transforming the majority of the world's population into vampires. Humans are now an endangered, second-class speciesforced into hiding as they are hunted and farmed for vampire consumption to the brink of extinction.
It's all up to Edward Dalton (Ethan Hawke), a vampire researcher who refuses to feed on human blood, to perfect a blood substitute that might sustain vampires and spare the few remaining humans. But time and hope are running outuntil Ed meets Audrey (Claudia Karvan), a human survivor who leads him to a startling medical breakthrough. Armed with knowledge that both humans and vampires will kill for, Ed must battle his own kind in a deadly struggle that will decide the fate of the human race.