Simon, John Candy, Felix, and The Drake are jerks. They are stupid, scheming, self-regarding dudes who are convinced of their own greatness. They are also convinced that they can fix their pathetic lives with self-help books.
Unfortunately for the guys, self-help is not moron-proof. The foursome's idiotic attempts at bettering themselves lead to lost jobs, poorly timed acid trips, incarceration, and a wild trip to Mexico.