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Nick Twisp (Michael Cera) is a sex-obsessed teen who falls hopelessly in love with Sheeni Saunders (Portia Doubleday) while on a family vacation. Sheeni is a beautiful, free spirited girl, but family, geography and jealous ex-lovers conspire to keep these two apart.

Inspired by Sheeni's free spirit, Nick abandons his dull, predictable life and develops a rebellious alter ego, Francois. Francois will stop at nothing to be with Sheeni and leads Nick on a path of destruction and on the run from local law enforcement that has uproarious and unpredictable consequences.