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On September 12, 2005 in Hollywood, California, Vince Vaughn took the stage at the Music Box Theater in Hollywood, California and began an unprecedented comedy tour featuring stand-up comedians Ahmed Ahmed, John Caparulo, Bret Ernst, and Sebastian Maniscalco. In the spirit of the old west variety shows, Vaughn played host to the ensemble of comedians and performed improvisational sketches with surprise celebrity guests.

Vince Vaughn's Wild West Comedy Show: 30 Days and 30 Nights - Hollywood to the Heartland chronicles the journey of Vaughn and the comedians as travel over 6,000 miles and perform 30 shows in 30 consecutive nights in cities across the nation. The film provides audiences with a rare opportunity to experience Vaughn and his team as bring their unique styles and perspectives to regional audiences throughout Western, Southern and Midwestern states.

Through rousing onstage performances and behind-the-scenes interviews, the engaging film breaks down the true essence of each comedian's life altering experiences and the personal and professional challenges that will unite four comics, one movie star and legions of fans from Hollywood to the Heartland.