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While on vacation in Los Angeles, Walter, the world's biggest Muppet fan, and his friends Gary (Jason Segel) and Mary (Amy Adams) from Smalltown, USA, discover that oilman Tex Richman (Chris Cooper) plans to raze the Muppet Theater so he can drill for the oil recently discovered beneath the Muppets' former stomping grounds.

To raise the $10 million needed to save the theater, Walter, Mary and Gary stage The Greatest Muppet Telethon Ever and help Kermit reunite the Muppets, who have all gone their separate ways: Fozzie now performs with a Reno casino tribute band called the Moopets, Miss Piggy is a plus-size fashion editor at Vogue Paris/36049/">Paris, Animal/45068/">Animal is in a Santa Barbara clinic for anger management, and Gonzo is a high-powered plumbing magnate.