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Andy Brewster (Seth Rogen) is an inventor who lives in Los Angeles. He's come up with an amazing organic cleaner but can't get anyone interested in manufacturing it.

Andy plans a business trip to promote the product and decides to take his mother (Barbara Streisand) along for the ride. She's been alone since his father died, so he comes up with a great idea—during the trip he'll surprise her with a stop in San Francisco, where one of her ex-flames lives.