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Nicolas Cage plays EMS paramedic Frank Pierce. It is the early 1990's and New York has not yet undergone its renaissance of recent years. Surrounded by the injured and the dying, Frank is dwelling in an urban night-world, crumbling under the accumulated weight of too many years of saving and losing lives.

The film follows Frank over the course of fifty-six hours in his life - two days and three nights on the job - as he reaches the very brink of spiritual collapse and redemption.