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Every year, one in 700 people wake up during surgery. When they planned her husband's murder, they never thought he'd be the one.

A young man named Clay (Hayden Christensen) undergoes heart surgery while experiencing a common occurrence called "anaesthetic awareness," a horrifying phenomenon which leaves him fully conscious but physically paralyzed during surgery. The patient's charming new wife (Jessica Alba) is forced to struggle with her own demons as a terrifying drama unfolds around the couple.