While one would imagine that the average New Yorker would be used to dealing with bugs after years of apartment dwelling, a scientific experiment gone wrong results in an insect that even Raid can't handle in this sci-fi/horror thriller.
In Manhattan, cockroaches are spreading a deadly disease that is claiming hundreds of the city's children, so entomologist Susan Tyler (Mira Sorvino) uses genetic engineering techniques to create what she and her colleague (and husband) Peter Mann (Jeremy Northam) call the Judas Breed, a large insect that will feed on the disease carrying roaches.
Since the Judas bugs have been designed so that they can't breed, the mutated species should die out in a matter of a few years. However, Susan, Peter, and their staff severely underestimated the cockroach's ability to adapt to its conditions.
The Judas Breed has indeed found a way to reproduce itself, but more importantly, the insect has grown remarkably large (sometimes reaching six feet in length), has developed a taste for meat, and can mimic the appearance and behavior of other creatures with uncanny accuracy -- including humans.
Susan and Peter have learned that huge swarms of the Judas Breed are living beneath the city in the subway system, and with the help of Leonard (Charles S. Dutton), a transit system employee who knows the labyrinth of subway tunnels like the back of his hand, they search out the humanoid insects before they can take over the city.